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The main reasons are as follows:

• Precise control of reaction conditions
  In the process of drug synthesis and manufacturing, many chemical reactions are extremely temperature sensitive and need to be carried out at specific temperatures. The cooling and heating system can ensure that the temperature inside the reaction vessel remains within the required range, ensuring reaction efficiency and product quality.

• Improve reaction efficiency
  Appropriate temperature control can accelerate reaction rates, shorten production time, and improve efficiency. Some reactions proceed faster at high temperatures, while others require low temperatures to avoid side reactions.

• Ensure product quality
  Temperature fluctuations may lead to side reactions or impurity formation, affecting drug purity and efficacy. The cooling and heating system can maintain a stable temperature, ensuring product consistency and high quality.

• Ensure safety
  Some reactions release a large amount of heat, and if not cooled in time, it may lead to temperature runaway and cause danger. The cooling system can quickly remove excess heat and prevent accidents from occurring.

• Adapt to different response needs
  There are multiple reactions involved in the pharmaceutical process, each with different temperature requirements. The cooling and heating system can be flexibly adjusted to meet the needs of different reactions.

When choosing the direct or secondary heat exchange type of TCU (temperature control unit), it needs to be determined based on specific application requirements, process conditions, and equipment characteristics. Here is a comparison and selection suggestion between the two:

Direct Type TCU

• Characteristic:
• Direct heating/cooling: The medium flows directly through the reaction vessel without undergoing secondary heat exchange.
• Simple structure: The system has fewer components and is relatively easy to install and maintain.
• Fast response speed: Rapid temperature adjustment, suitable for processes that require rapid temperature changes.

Secondary heat exchange Type TCU

• Characteristic:
• Indirect heating/cooling: The temperature of the reaction vessel is indirectly controlled through a heat exchanger, and the medium does not directly contact the reactants.
• Complex structure: The system includes additional heat exchangers, making installation and maintenance more complex.
• Accurate temperature control: suitable for processes that require extremely high temperature control.

Choose Suggestions

1.Process requirements:

• If rapid temperature change and medium compatibility are required, a straight through type can be selected.
• If high temperature control accuracy is required or the medium is incompatible, choose the secondary heat exchange type.

2.Media compatibility:

• When the medium is compatible, the straight through type is more convenient.
• When the medium is incompatible, the secondary heat exchange type is safer.

3.Temperature range:

• The medium low temperature or medium high temperature process can be selected as a straight through type.
• The extreme temperature process should choose the secondary heat exchange type.

4.Cleanliness requirements:

• For high cleanliness requirements, the secondary heat exchange type is more suitable.

5.Space and maintenance:

• Due to limited space or a desire to simplify maintenance, a straight through option is available.
• Acceptable for complex installation and maintenance, optional secondary heat exchange type.